| 发明名称 |
STEROID ANTIBIOTIC CONJUGATES |
| 摘要 |
The present invention describes steroid antibiotic conjugates. These single drug entities are formed connecting a steroid moiety and two same antibiotics moieties, or a steroid moiety and two different antibiotics moieties. Upon topical application to the eye, the conjugate hybrid would undergo enzymatic and/or hydrolytic cleavage to release the individual drugs. |
| 申请公布号 |
US2014256694(A1) |
申请公布日期 |
2014.09.11 |
| 申请号 |
US201414199212 |
申请日期 |
2014.03.06 |
| 申请人 |
Allergan, Inc. |
发明人 |
Sinha Santosh C.;Chow Ken;WANG LIMING;GARST MICHAEL E.;ATTAR MAYSSA;SWIFT BRANDON D. |
| 分类号 |
A61K47/48;A61K9/00 |
主分类号 |
A61K47/48 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A hybrid compound comprising a steroid and two antibiotic moieties, or a pharmaceutical salt thereof, which are connected via separate covalent bonds to at least one linker each such that said covalent bond degrade in vivo to yield the respective two antibiotics independently and the respective steroid drug. |
| 地址 |
Irvine CA US |
