ARGININE-FREE TNFR:FC-FUSION POLYPEPTIDE COMPOSITIONS AND METHODS OF USE

摘要

Aspects of the invention are directed to arginine-free polypeptide-containing compositions and methods for treating disorders associated with inflammation or the autoimmune response. In particular, the polypeptide is etanercept.

主权项

1. A composition, comprising:
an isolated polypeptide that is an extracellular ligand-binding portion of a human p75 tumor necrosis factor receptor fused to the Fc region of a human IgGl; and salt in an amount sufficient to prevent aggregation of the isolated polypeptide, thereby stabilizing the composition, wherein the composition comprises L-arginine at a concentration of less than 1 mM.