Stabilized Variant MAML Peptides and Uses Thereof

摘要

Internally cross-linked peptides derived from human MAML and derivatives thereof which exhibit affinity for the ICN1-CSL complex are described and characterized. The peptides can interfere with NOTCH signaling and are thus useful for treating various disorders, including certain cancers.

主权项

1. An internally cross-linked polypeptide comprising the amino acid sequence of any of SEQ ID NOs 12-20, wherein the side chains of at least two amino acids separated by three or six amino acids are replaced by an internal cross-link.