| 主权项 |
1. A compound of formula I:or a pharmaceutically acceptable salt thereof, wherein:
Ht is Ring D is a 4-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from a heterocyclyl or a carbocyclyl ring; said heterocyclyl ring having 1-4 ring heteroatoms selected from nitrogen, oxygen or sulfur, wherein each substitutable ring carbon of Ring D is independently substituted with oxo or —R5, and any substitutable ring nitrogen is independently substituted with —R4; X is sulfur, oxygen, or NR2′; Y is nitrogen or CR2; Z1 and Z2 are each independently N or CR9; provided that at least one of Z1 or Z2 is N and at least one of Z1 or Z2 is CR9; RX is T1-R3; RY is T2-R10; R2 and R2′ are independently selected from —R or -T3-W—R6; or R2 and R2′ are taken together with their intervening atoms to form a fused, 5-8 membered, unsaturated or partially unsaturated, ring having 0-3 ring heteroatoms selected from nitrogen, oxygen, or sulfur, wherein each substitutable carbon on said fused ring formed by R2 and R2′ is substituted with halo, oxo, —CN, —NO2, —R7, or —V—R6, and any substitutable nitrogen on said ring formed by R2 and R2′ is substituted with R4; each T, T1 and T3 is independently a bond or a C1-4 alkylidene chain; T2 is independently a bond or a C1-4 alkylidene chain wherein up to three methylene units of the alkylidene chain are optionally replaced by —O—, —C(═O)—, —S(O)—, —S(O)2—, —S—, or —N(R4)—; R3 is selected from —R, -halo, —OR, —C(═O)R, —CO2R, —COCOR, —COCH2COR, —NO2, —CN, —S(O)R, —S(O)2R, —SR, —N(R4)2, —CON(R7)2, —SO2N(R7)2, —OC(═O)R, —N(R7)COR, —N(R7)CO2R″, —N(R4)N(R4)2, —C(═NH)N(R4)2, —C(═NH)—OR, —N(R7)CON(R7)2, —N(R7)SO2N(R7)2, —N(R4)SO2R, or —OC(═O)N(R7)2; each R4 is independently selected from —R7, —COR7, —CO2 (optionally substituted C1-6 aliphatic), —CON(R7)2, or —SO2R7, or two R4 on the same nitrogen are taken together to form a 3-8 membered heterocyclyl or heteroaryl ring; each R5 is independently selected from —R, halo, —OR, —C(═O)R, —CO2R, —COCOR, —NO2, —CN, —S(O)R, —SO2R, —SR, —N(R4)2, —CON(R4)2, —SO2N(R4)2, —OC(═O)R, —N(R4)COR, —N(R4)CO2R″, —N(R4)N(R4)2, —C═NN(R4)2, —C═N—OR, —N(R4)CON(R4)2, —N(R4)SO2N(R4)2, —N(R4)SO2R, or —OC(═O)N(R4)2; V is —O—, —S—, —SO—, —SO2—, —N(R6)SO2—, —SO2N(R6)—, —N(R6)—, —CO—, —CO2—, —N(R6)CO—, —N(R6)C(O)O—, —N(R6)CON(R6)—, —N(R6)SO2N(R6)—, —N(R6)N(R6)—, —C(O)N(R6)—, —OC(O)N(R6)—, —C(R6)2O—, —C(R6)2S—, —C(R6)2SO—, —C(R6)2SO2—, —C(R6)2SO2N(R6)—, —C(R6)2N(R6)—, —C(R6)2N(R)C(O)—, —C(R6)2N(R6)C(O)O—, —C(R6)═NN(R6)—, —C(R6)═N—O—, —C(R6)2N(R6)N(R6)—, —C(R6)2N(R6)SO2N(R6)—, or —C(R6) 2N(R6)CON(R6)—; W is —C(R6)2O—, —C(R6)2S—, —C(R6)2SO—, —C(R6)2SO2—, —C(R6)2SO2N(R6)—, —C(R6)2N(R6)—, —CO—, —CO2—, —C(R6)2OC(O)—, —C(R6)2OC(O)N(R6)—, —C(R6)2N(R6)CO—, —C(R6)2N(R6)C(O)O—, —C(R6)═NN(R6)—, —C(R6)═N—O—, —C(R6)2N(R6)N(R6)—, —C(R6)2N(R6)SO2N(R6)—, —C(R6)2N(R6)CON(R6)—, or —CON(R6)—; each R6 is independently selected from hydrogen or C1-4 aliphatic group optionally substituted with 0-3 J6; or two R6 groups on the same nitrogen atom are taken together with the nitrogen atom to form a 4-6 membered heterocyclyl or heteroaryl ring, wherein said heterocyclyl or heteroaryl ring is optionally substituted with 0-4 J6; each R7 is independently selected from hydrogen or R″; or two R7on the same nitrogen are taken together with the nitrogen to form a 4-8 membered heterocyclyl or heteroaryl ring, wherein said heterocyclyl or heteroaryl ring is optionally substituted with 0-4 J7; each R9 is —R′, -halo, —OR′, —C(═O)R′, —CO2R′, —COCOR′, COCH2COR′, —NO2, —CN, —S(O)R′, —S(O)2R′, —SR′, —N(R′)2, —CON(R′)2, —SO2N(R′)2, —OC(═O)R′, —N(R′)COR′, —N(R′)CO2(C1-6 aliphatic), —N(R′)N(R′)2, —N(R′)CON(R′)2, —N(R′)SO2N(R′)2, —N(R′)SO2R′, —OC(═O)N(R′)2, ═NN(R′)2, ═N—OR′, or ═O; each R10 is a 4-membered heterocyclic ring containing 1-2 heteroatoms selected from O, NR11, and S; each R10 is optionally substituted with 0-3 occurrences of J; each R1 is —R7, —COR7, —CO2 (optionally substituted C1-6 aliphatic), —CON(R7)2, or —SO2R7; each R is independently selected from hydrogen or an optionally substituted group selected from C1-6 aliphatic, C6-10 aryl, a heteroaryl ring having 5-10 ring atoms, or a heterocyclyl ring having 4-10 ring atoms; each R is optionally substituted with 0-5 R9; each R′ is independently hydrogen or a C1-6 aliphatic group optionally substituted with 0-4 J′; or two R′, together with the atom(s) to which they are attached, form a 3-6 membered carbocyclyl or heterocyclyl wherein said carbocyclyl or heterocyclyl is optionally substituted with 0-4 J′; each R″ is independently C1-6 aliphatic optionally substituted with 0-4 J″; each J′ and J″ is independently NH2, NH(C1-4aliphatic), N(C1-4aliphatic)2, halogen, C1-4aliphatic, OH, O(C1-4aliphatic), NO2, CN, CO2H, CO2(C1-4aliphatic), O(haloC1-4 aliphatic), or haloC1-4aliphatic; each J, J6, and J8 is independently -halo, —OR, oxo, C1-6 aliphatic, —C(═O)R, —CO2R, —COCOR, COCH2COR, —NO2, —CN, —S(O)R, —S(O)2R, —SR, —N(R4)2, —CON(R7)2, —SO2N(R7)2, —OC(═O)R, —N(R7)COR, —N(R7)CO2(C1-6 aliphatic), —N(R4)N(R4)2, ═NN(R4)2, ═N—OR, —N(R7)CON(R7)2, —N(R7)SO2N(R7)2, —N(R4)SO2R, or —OC(═O)N(R7)2; each J7 is independently -halo, —OR, oxo, C1-6 aliphatic, —C(═O)R, —CO2R, —COCOR, COCH2COR, —NO2, —CN, —S(O)R, —S(O)2R, —SR, —N(R1)2, —CON(R1)2, —SO2N(R12)2, —OC(═O)R, —N(R12)COR, —N(R1)CO2(C1-6 aliphatic), —N(R1)N(R1)2, ═NN(R1)2, ═N—OR, —N(R1)CON(R1)2, —N(R1)SO2N(R1)2, —N(R1)SO2R, or —OC(═O)N(R12)2; or 2 J groups, 2 J6 groups, 2 J7 groups, or 2 J8 groups, on the same atom or on different atoms, together with the atom(s) to which they are bound, form a 3-8 membered saturated, partially saturated, or unsaturated ring having 0-2 heteroatoms selected from O, N, or S; R12 is independently selected from hydrogen or R″; or two R12 on the same nitrogen are taken together with the nitrogen to form a 4-8 membered heterocyclyl or heteroaryl ring, wherein said heterocyclyl or heteroaryl ring is optionally substituted with 0-4 J″. |
