ANTIBIOTIC CONJUGATES DIRECTLY LINKED WITH STEROID DRUGS

摘要

The present invention describes novel single drug entities, formed by direct linkage of an antibiotic to a steroidal drug. Upon topical application to the eye, the conjugate would undergo enzymatic and/or hydrolytic cleavage to release the individual drugs. The antibiotic is coupled directly to the steroid drug.

主权项

1. A hybrid drug comprising one antibiotic moieties and one steroid moiety, or a pharmaceutical salt thereof, which are connected via two separate covalent bonds to each other such that said covalent bond degrades in vivo to yield the respective antibiotic and steroid independently.