| 发明名称 |
Compositions and Methods for Inhibiting Expression of XBP-1 Gene |
| 摘要 |
The invention relates to a double-stranded ribonucleic acid (dsRNA) targeting X-Box Protein 1 (XBP-1), and methods of using the dsRNA to inhibit expression of XBP-1. |
| 申请公布号 |
US2014256791(A1) |
申请公布日期 |
2014.09.11 |
| 申请号 |
US201414283142 |
申请日期 |
2014.05.20 |
| 申请人 |
Alnylam Pharmaceuticals, Inc. |
发明人 |
Fitzgerald Kevin;Hinkle Gregory |
| 分类号 |
C12N15/113 |
主分类号 |
C12N15/113 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A double-stranded ribonucleic acid (dsRNA), wherein said dsRNA comprises at least two sequences that are complementary to each other and wherein a sense strand comprises a first sequence and an antisense strand comprises a second sequence comprising a region of complementarity which is substantially complementary to at least a part of an mRNA encoding X-Box Protein 1 (XBP-1), and wherein said region of complementarity is less than 30 nucleotides in length. |
| 地址 |
Cambridge MA US |
