SUBSTITUTED HETEROCYCLIC AMINE COMPOUNDS AS CHOLESTRYL ESTER-TRANSFER PROTEIN (CETP) INHIBITORS

摘要

The present application relates to cycloalkylpyridin-2-amines derivates of formula (1) or stereoisomers thereof or pharmaceutically acceptable salts thereof. The present application also relates to the process for the preparation of compounds of formula (I). The present application further describes the compounds of formula (1) as cholesteryl ester-transfer protein (CETP) inhibitors. The present application further relates to pharmaceutical compositions comprising compounds of formula (1) or stereoisomers thereof or pharmaceutically acceptable salts thereof.;

主权项

1. A compound having the formula (I), or a stereoisomer thereof or a pharmaceutically acceptable salt thereof: wherein, R represents R1 and R2 are independently selected from hydrogen, acyl, haloalkyl,—(CHRe)qR3, an optionally substituted group selected from alkyl or cycloalkyl, wherein optional substituent, in each occurrence, is independently selected from halogen, cyano, hydroxyl, an alkyl, a haloalkyl or an alkoxy; R3 is a group selected from alkoxy, haloalkoxy, cycloalkyl, aryl, heterocyclyl or heteroaryl, wherein R3 is optionally substituted with a group selected from halogen, cyano, hydroxyl, alkyl, haloalkyl or alkoxy; Ra, in each occurrence, is independently selected from cyano, hydroxy, alkyl, haloalkyl or alkoxy; Rb, in each occurrence, is independently selected from halogen, alkyl, haloalkyl, hydroxy, alkoxy or haloalkoxy; Rc is independently selected from hydrogen, cyano, halogen, —C(═O)—Rf, —CONRgRh, —C(═O)—CH≡CH—NRiRj, an optionally substituted group selected from cycloalkyl, aryl, heteroaryl or heterocyclyl ring, wherein the optional substituent, in each occurrence, is selected independently from hydrogen, halogen, cyano, hydroxyl, alkyl, haloalkyl, alkoxy, alkoxyalkyl or haloalkoxy; Rd is hydrogen or alkyl; Re, in each occurrence, is independently selected from hydrogen, alkyl or alkoxy; Rf is hydrogen or alkyl; Rg, Rh, Ri and Rj are independently represent hydrogen or alkyl; m is 0, 1 or 2; n is 0, 1, 2 or 3; p is 1 or 2; and q is 0, 1, 2, 3, 4 or 5.