Treatment of Muscular Conditions and Muscular Dystrophies

摘要

The present invention provides methods for improving muscular function or treating a muscular disorder in an individual by administering to the individual a pharmacologically effective amount of a compound that inhibits microtubule-dependent NADPH Oxidase 2 reactive oxygen species signaling production. In addition compounds that block sarcolemmal Ca2+ channel activation and/or renin-angiotensin signaling may be administered with the inhibitor of microtubule-dependent NADPH Oxidase 2 reactive oxygen species signaling production.

主权项

1. A method of improving muscular function in an individual, comprising the step of:
administering to said individual a pharmacologically effective amount of a compound that inhibits microtubule-dependent NADPH Oxidase 2 reactive oxygen species signaling production, wherein reduction in microtubule-dependent NADPH Oxidase 2 reactive oxygen species signaling production improves muscular function in said individual.