发明名称 |
Specific active site inhibitors of enzymes or substrate binding partners and methods of producing same |
摘要 |
The present disclosure provides a method of producing enzyme-specific inhibitors or substrate binding partners comprising: identifying active site residues of the substrate in the enzyme substrate complex or in substrate binding partner-substrate complex; randomizing the active site residues to produce a combinatorial library of substrate variants; and selecting substrate variants that inhibit enzyme activity or bind substrate as substrate-specific binding partners. The present disclosure also provides ubiquitin enzyme specific inhibitors and ubiquitin variants that bind ubiquitin interaction motifs. |
申请公布号 |
EP2719707(A3) |
申请公布日期 |
2014.09.10 |
申请号 |
EP20130185248 |
申请日期 |
2011.06.08 |
申请人 |
THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO |
发明人 |
SIDHU, SACHDEV;BEATTY, LINDA;ERNST, ANDREAS |
分类号 |
C07K14/47 |
主分类号 |
C07K14/47 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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