| 摘要 |
The present application relates to novel HIV-1 envelope glycoproteins, which may be utilized as HIV-1 vaccine immunogens, and antigens for crystallization, electron micrsocopy and other biophysical, biochemical and immunological studies for the identification of broad neutralizing antibodies. The present invention encompasses the preparation and purification of immunogenic compositions, which are formulated into the vaccines of the present invention. |
| 申请人 |
INTERNATIONAL AIDS VACCINE INITIATIVE;THE SCRIPPS RESEARCH INSTITUTE;WEILL CORNELL MEDICAL COLLEGE;HOFFENBERG, SIMON;CAULFIELD, MICHAEL;DEAN, HANSI;KING, C. RICHTER;MOORE, JOHN;KLASSE, PER JOHAN;SANDERS, ROGIER;CUPO, ALBERT;MAROZSAN, ANDRE;WILSON, IAN, A.;WARD, ANDREW;JULIEN, JEAN-PHILIPPE |
发明人 |
HOFFENBERG, SIMON;CAULFIELD, MICHAEL;DEAN, HANSI;KING, C. RICHTER;MOORE, JOHN;KLASSE, PER JOHAN;SANDERS, ROGIER;CUPO, ALBERT;MAROZSAN, ANDRE;WILSON, IAN;WARD, ANDREW;JULIEN, JEAN-PHILLIPPE |
