发明名称 |
CHROMATOGRAPHY PROCESS FOR RESOLVING HETEROGENEOUS ANTIBODY AGGREGATES |
摘要 |
<p>Disclosed are methods and processes utilizing multi-modal chromatography as a polishing step to separate heterogeneously charged (basic and acidic) aggregates and other impurities from partially a partially purified bulk product monoclonal antibody product. The resulting chromatographic process provides a scaleable production process that is cost effective and increases the productivity of the purification process over a platform utilizing a combination of anion and cation exchange chromatography to resolve heterogeneous aggregates.</p> |
申请公布号 |
EP2773439(A1) |
申请公布日期 |
2014.09.10 |
申请号 |
EP20120846186 |
申请日期 |
2012.10.25 |
申请人 |
MERCK SHARP & DOHME CORP. |
发明人 |
NTIGYABAAH, JOSEPH;MEISSNER, SANDRA;CHMIELOWSKI, REBECCA;KONIETZKO, JANELLE |
分类号 |
C12P21/08;B01D15/36;B01D15/38;C07K16/00;C07K16/24 |
主分类号 |
C12P21/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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