发明名称 |
CLATHRATE COMPLEX OF CYCLODEXTRIN OR ARABINOGALACTAN WITH 9-PHENYL-SYM-OCTAHYDROSELENOXANTHENE |
摘要 |
<p>The invention relates to novel clathrate complexes of cyclodextrin or arabinogalactan with 9-phenyl-sym-octahydroselenoxanthene, possibly in ±-crystalline form, with a mass ratio of 9-phenyl-sym-octahydroselenoxanthene:cyclodextrin of from 1:3 to 1:30 or 9-phenyl-sym-octahydroselenoxanthene:arabinogalactan of from 1:10 to 1:20. The clathrate complex may be in crystalline form, possibly in the form of nano-particles with a size of less than 100 nm. In the clathrate complex, cyclodextrin is selected from ±-, ²-, ³- or hydroxypropyl-²-cyclodextrin, primarily ²-cyclodextrin. The proposed clathrate complexes make it possible to increase the water-solubility of the active compound, to improve the bioavailability, to reduce the dosage of the drug and, consequently, to reduce the toxic effect of 9-phenyl-sym-octahydroselenoxanthene. The complexes exhibit cytoradioprotective activity. The invention also relates to a liquid-phase and solid-phase methods for producing clathrate complexes, as well as to pharmaceutical compositions and drugs thereof.</p> |
申请公布号 |
EP2679584(A4) |
申请公布日期 |
2014.09.10 |
申请号 |
EP20120750125 |
申请日期 |
2012.02.20 |
申请人 |
OBSCHESTVO S OGRANICHENNOY OTVETSTVENNOSTYU «NAUCHNO-ISSLEDOVATELSKAYA KOMPANIYA «MEDBIOPHARM» |
发明人 |
TSYB, ANATOLIY FEDOROVICH;GONCHAROVA, ANNA YAKOVLEVNA;ROZIEV, RAHIMDZHAN AHMETDZHANOVICH;VOROBYEV, ILYA VLADIMIROVICH;PODGORODNICHENKO, VLADIMIR KONSTANTINOVICH;ERIMBETOV, KENES TAGAYEVICH |
分类号 |
C07D345/00;A61K31/095;A61K47/36;A61K47/40;A61P39/00;C08B37/00 |
主分类号 |
C07D345/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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