CARBOXYLIC MANNAN-COATED CONTRAST AGENT FOR MAGNETIC RESONANCE IMAGING
摘要
The present invention relates to a magnetic resonance imaging (MRI) contrast agent coated with carboxylated mannan, particularly a carboxylated mannan coated superparamagnetic MRI contrast agent specifically targeting antigen presenting cells and having excellent in vivo stability, and a method for producing the same. The MRI contrast agent coated with carboxylated mannan of the present invention can provide excellent in vivo stability and biocompatibility owing to its high surface negative charge, and can be introduced specifically into antigen presenting cells owing to mannose of mannan, so as to visualize the antigen presenting cells and the tissue containing the antigen presenting cells in MRI.
申请公布号
EP2679247(A4)
申请公布日期
2014.09.10
申请号
EP20110860590
申请日期
2011.03.08
申请人
INTRON BIOTECHNOLOGY, INC.
发明人
YOON, SEONG JUN;JUN, SOO YOUN;KWON, AN SUNG;KANG, SANG HYEON;JEONG, YONG YEON;PARK, IN KYU;CHO, CHONG SU;KIM, YOU KYOUNG;KIM, WON JONG;NAMGUNG, RAN