| 摘要 |
FIELD: chemistry.SUBSTANCE: claimed invention relates to systems of a film coating for preparations with an immediate release for application on peroral dosed forms, such as pressed tablets and other perorally administered substrates, which possess an improved barrier protection means against moisture. The film coating composition contains 28-5 wt % of polyvinyl alcohol, 1-8 wt % of a polymer with pH-dependent solubility and, optionally, a plasticiser, a lubricant, an anti-adhesion substance, an alkalising substance and a pigment. Preferably, the polymer with pH-dependent solubility represents a copolymer of methacrylic acid and polyvinylacetophthalate (PVAP). Also described are compositions of the film coating, containing water suspension of powder mixtures, methods of applying the coatings on substrates and the substrates with the coating.EFFECT: invention provides fast disintegration of the compositions in a medium with different pH (less than 30 minutes) and satisfactory characteristics of the anti-moisture barrier.18 cl, 1 tbl, 27 ex |
