发明名称 |
Polypeptides, antibody variable domains and antagonists |
摘要 |
The invention relates to anti-TNFR1 polypeptides and antibody single variable domains (dAbs) that are resistant to degradation by a protease, as well as antagonists comprising these. The polypeptides, dAbs and antagonists are useful for as therapeutics and/or prophylactics that are likely to encounter proteases when administered to a patient, for example for pulmonary administration, oral administration, delivery to the lung and delivery to the GI tract of a patient, as well as for treating inflammatory disease, such as arthritis or COPD. |
申请公布号 |
EP2746290(A3) |
申请公布日期 |
2014.09.10 |
申请号 |
EP20130184209 |
申请日期 |
2008.06.04 |
申请人 |
DOMANTIS LIMITED |
发明人 |
JESPERS, LAURENT;PUPECKA, MALGORZATA;TOMLIMSON, IAN;ENEVER, CAROLYN |
分类号 |
C07K16/00;A61K9/00;C07K16/22;C07K16/28 |
主分类号 |
C07K16/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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