发明名称 |
FORMULATIONS FOR THE TREATMENT OF DIABETES |
摘要 |
<p>Disclosed is a formulation for parenteral administration comprising insulin that comprises a pH memory between 1 to 4 or between 6 to 8 and an aprotic polar solvent, wherein the insulin is solubilized in the aprotic polar solvent, wherein the solubilized insulin comprises stable monomeric or dimeric forms of insulin or mixtures thereof, and wherein the water content of the formulation is equal to or less than 15% w/v.</p> |
申请公布号 |
EP2773331(A1) |
申请公布日期 |
2014.09.10 |
申请号 |
EP20120798470 |
申请日期 |
2012.10.31 |
申请人 |
XERIS PHARMACEUTICALS, INC. |
发明人 |
PRESTRELSKI, STEVEN;SCOTT, NANCY |
分类号 |
A61K9/00;A61K9/14;A61K9/19;A61K38/22;A61K38/28;A61K47/20 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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