| 摘要 |
FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to isoindoline compounds, such as compounds of Formulaor to their pharmaceutically acceptable salts or stereoisomers, wherein X represents CH; Y represents O, cyanamido (N-C?N) or amido (NH); m represents an integer of 0 or 1; Rrepresents hydrogen or Calkyl; Rrepresents hydrogen, Calkyl, Calkyl-(5-10-merous heteroaryl containing one, two or three heteroatoms independently specified in O, S or N), Calkyl-(6-merous heterocyclyl which represents morpholinyl or piperazinyl), Calkyl-OH, -NHCO-Calkyl, -ORor - (CH-Z)-(6-merous heteroaryl which represents pyridinyl), wherein each heteroaryl and heterocyclyl is optionally substituted by one or more Calkyls; Rrepresents hydrogen, halogen, -NO, Calkyl-OH, Calkyl-NHor -OR; Rrepresents phenyl, pyridinyl, piperidinyl or -CO(CH)R; Rrepresents -NHor piperazinyl; and Z represents O; provided Rrepresents hydrogen, then Ris other than hydrogen or Calkyl; provided Rrepresents halogen, then Rrepresents Calkyl-(5-6-merous heterocyclyl). The invention also refers to pharmaceutical compositions for controlling angiogenesis or inhibiting the TNF? production on the basis of the above compounds.EFFECT: there are prepared new compounds and compositions based thereon to be used in medicine for treating or preventing a disease or a disorder, such as cancer, pain skin diseases, lung disorders, parasitic diseases, immunodeficiency disorders, CNS disorders, CNS injuries, atherosclerosis or associated disorders, sleep disorders or associated disorders.26 cl, 68 ex |
