Susceptibility variants for lung cancer

摘要

The present invention discloses certain genetic variants as susceptibility variants for lung cancer. The invention relates to methods of risk assessment using such variants. The invention further relates to kits for use in risk assessment of lung cancer.

主权项

1. A method for determining a susceptibility to lung cancer in a human individual, comprising:
assaying a nucleic acid sample from the individual for an allele of a polymorphic marker, said allele being rs1051730 allele T, rs16969968 allele A, rs8034191 allele C, or ss107794645 allele C; detecting the allele in the nucleic acid sample; determining that the individual has an increased genetic susceptibility to lung cancer from the detection of the allele in the nucleic acid sample; and screening the human individual determined to have the increased genetic susceptibility to lung cancer for lung cancer using at least one procedure selected from a chest x-ray, sputum cytology examination, and low dose computed tomography scan.