In situ formation of an artificial blockage to control bleeding by polymer expansion with hydrogen peroxide

摘要

A composition for in situ formation of an artificial blockage to control bleeding includes a suitable amount of a polymer-forming component, a suitable amount of a crosslinking agent, hydrogen peroxide, and a decomposing agent for hydrogen peroxide. The decomposing agent includes exogenous or endogenous catalase, or both.

主权项

1. An injection method for in situ formation of a pressurized obstruction in a wound or body cavity to control bleeding, comprising the steps of:
a) providing a first component comprising hydrogen peroxide having a concentration of about 20% to about 100% by volume or weight; b) providing a second component comprising an expandable component comprising polyacrylate; c) delivering the first and second components separately, but substantially simultaneously by injection into a wound or body cavity; d) allowing blood to come in contact with the hydrogen peroxide, thereby producing a gas; and e) allowing the gas to come in contact with the polyacrylate, thereby producing an expanded mass within 5 seconds to 45 seconds forming a pressurized obstruction to control bleeding in the wound or body cavity.