Amino acid vitamin ester compositions for controlled delivery of pharmaceutically active compounds

摘要

The invention relates to pharmaceutical compositions that provide sustained-release of a pharmaceutically active compound and to methods of treating or preventing a condition in an animal by administering the pharmaceutical compositions to the animal. When the pharmaceutical compositions are administered to an animal by injection, they form a drug depot that releases the pharmaceutically active compound over time. The pharmaceutical compositions can also be administered orally.

主权项

1. A pharmaceutical composition comprising:
(i) a protonated oligonucleotide, (ii) an amino acid-vitamin ester, and (iii) a pharmaceutically acceptable organic solvent,wherein the pharmaceutical composition is injectable and forms a precipitate when injected into water.