Bifunctional molecules for inhibiting HIV entry

摘要

Disclosed herein are bifunctional molecules which inhibit HIV entry into the target cell. Also disclosed are novel anti-HIV therapeutics for treatment of patients infected by HIV, including non-B and multi-drug resistant strains.

主权项

1. A bifunctional protein consisting essentially of:
a first C-terminal heptad repeat (CHR) peptide of a human immunodeficiency virus 1 (HIV-1) gp41 containing a pocket-binding domain and a heptad repeat (HR)-binding domain, wherein said first CHR peptide is directly linked to; a flexible linker comprising the amino acid sequence (GGGGS)n, wherein n is an integer between 6 and 8 (SEQ ID NOs:39, 40 and 41), which in turn is directly linked to; a second CHR peptide of an HIV-1 gp41 containing a HR-binding domain and a tryptophan-rich domain.