Methods for the therapy of inflammatory bowel disease using a type-1 interferon antagonist

摘要

Compositions and methods for the therapy of Inflammatory Bowel Disease (IBD), including Celiac Disease, Crohn's Disease, and Ulcerative Colitis, are disclosed. Illustrative compositions comprise one or more anti-type 1 interferon antagonists, such as anti-type 1 interferon receptor antibody antagonists and fragments thereof, as well as polypeptides and small molecules that inhibit the interaction of type 1 interferon with its receptor (IFNAR).

主权项

1. A method of treating a patient afflicted with Crohn's disease or ulcerative colitis, comprising (a) administering to said patient at a first time point a tolerizing dose of a first type 1 interferon antagonist which is a chimeric, humanized or human anti-type 1 interferon receptor antibody, and (b) administering to said patient at a second time point a therapeutically effective dose of a second type 1 interferon antagonist which is an anti-type 1 interferon alpha antibody.