| 发明名称 | Expansion of haemopoietic precursors | ||
| 摘要 | The present invention relates to a method of transplanting haematopoietic precursor cells into a subject in need thereof which involves culturing the haematopoietic precursor cells in the presence of a population of cells enriched for STRO-1bright cells. The method of the present invention is useful in the treatment of haematological disorders. | ||
| 申请公布号 | US8828375(B2) | 申请公布日期 | 2014.09.09 |
| 申请号 | US200913061693 | 申请日期 | 2009.09.03 |
| 申请人 | Mesoblast, Inc. | 发明人 | Itescu Silviu;Schuster Michael David |
| 分类号 | A61K38/20;A61K35/14;A61K38/19;A61P35/02;A61P35/00;A61P7/00;A61P19/02;A61P31/12;A61P31/06;A61P7/06;C12N5/0789;A61K35/12 | 主分类号 | A61K38/20 |
| 代理机构 | Cooper & Dunham LLP | 代理人 | White John P.;Cooper & Dunham LLP |
| 主权项 | 1. A method of transplanting haematopoietic precursor cells into a subject in need thereof, the method comprising: culturing haematopoietic precursor cells in the presence of a population of cells enriched for STRO-1bright cells or supernatant or progeny derived therefrom, wherein such STRO-1bright cells are mesenchymal precursor cells (MPC) which comprise mesenchymal precursor cells capable of giving rise to colony forming unit-fibroblasts (CFU-F), so as to expand the haematopoietic precursor cells; and administering the expanded haematopoietic precursor cells to a subject, wherein haematopoietic reconstitution occurs in the subject within 10 to 30 days of administration of the expanded haematopoietic precursor cells. | ||
| 地址 | New York NY US | ||