发明名称 |
Particulate materials |
摘要 |
Embodiments of the invention relate to particles of active substances, methods for preparing the particles, formulations containing the particles, and metered dose inhalers containing such particles or formulations. In one embodiment, a composition of an aerosol formulation is provided and contains a particulate active substance of non-micronized, solid particles having a mass median aerodynamic diameter of less than 10 μm suspended in a hydrofluorocarbon fluid vehicle at a concentration within a range from about 0.2% w/v to about 5% w/v. The aerosol formulation exhibits a flocculation volume of about 85% or greater about 1 minute after mixing the particulate active substance and the hydrofluorocarbon fluid vehicle. The particulate active substance contains an alkaloid ergotamine, pharmaceutically acceptable salts thereof, analogs thereof, or derivatives thereof. In some examples, the alkaloid ergotamine contains dihydroergotamine, such as dihydroergotamine mesylate and the hydrofluorocarbon fluid vehicle contains HFA 134a, HFA 227ea, or mixtures thereof. |
申请公布号 |
US8828359(B2) |
申请公布日期 |
2014.09.09 |
申请号 |
US201313908540 |
申请日期 |
2013.06.03 |
申请人 |
Nektar Therapeutics |
发明人 |
Kordikowski Andreas;Walker Stephen Ernest;York Peter |
分类号 |
A61K9/14;A61K9/12;B01J2/04;A61K9/00 |
主分类号 |
A61K9/14 |
代理机构 |
Patterson & Sheridan, LLP |
代理人 |
Patterson & Sheridan, LLP |
主权项 |
1. Particles of an active substance, wherein the particles are non-micronized, solid, have a mass median aerodynamic diameter of less than 10 μm, and exhibit a flocculation volume of about 85% or greater about 1 minute after mixing the particles with a nonsolvent hydrofluorocarbon fluid vehicle at a concentration within a range from about 0.2% w/v to about 5% w/v,
wherein the active substance comprises an ergot alkaloid, pharmaceutically acceptable salts thereof, analogues thereof, or derivatives thereof. |
地址 |
San Francisco CA US |