| 发明名称 |
Antibodies that bind tyrosyl-tRNA synthetases |
| 摘要 |
Hematopoietic-modulating compositions are provided comprising aminoacyl-tRNA synthetase polypeptides, including active fragments and/or variants thereof, as well as compositions comprising related agents such as antibodies and other binding agents. Also provided are methods of using such compositions in the treatment of conditions that benefit from the modulation of hematopoiesis. |
| 申请公布号 |
US8828395(B2) |
申请公布日期 |
2014.09.09 |
| 申请号 |
US201113162559 |
申请日期 |
2011.06.16 |
| 申请人 |
aTyr Pharma, Inc. |
发明人 |
Watkins Jeffry Dean;Vasserot Alain P.;Belani Rajesh;Greene Leslie Ann;Adams Ryan Andrew |
| 分类号 |
A61K39/395;C07K16/40 |
主分类号 |
A61K39/395 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An isolated antibody that exhibits binding specificity for an isolated tyrosyl-tRNA synthetase (YRS) polypeptide of SEQ ID NO:1, 2 or 3, wherein affinity of the antibody for the YRS polypeptide of SEQ ID NO:2 or 3 is at least about 1.5× stronger than its affinity for the YRS polypeptide of SEQ ID NO:1. |
| 地址 |
San Diego CA US |
