Pharmaceutical gels and methods for delivering therapeutic agents to a site beneath the skin

摘要

Pharmaceutical gels and methods for delivering a therapeutic agent to a target tissue site beneath the skin of a patient are provided, the gel being capable of adhering to the target tissue site and comprising one or more biodegradable depots containing an effective amount of the therapeutic agent. In various embodiments, the gel is sprayable and hardens after contacting the target tissue site.

主权项

1. A liquid gel for delivering a therapeutic agent to a target tissue site beneath the skin of a patient, the liquid gel being capable of adhering to and hardening to fill a void at the target tissue site and comprising one or more biodegradable depots containing an effective amount of the therapeutic agent, wherein the target tissue site comprises at least one cartilage, spinal disc, spinal foraminal space near the spinal nerve root, facet or synovial joint, or spinal canal, wherein the gel has a pre-dosed modulus of elasticity of 2×105 to about 5×105 dynes/cm2 and a post-dosed modulus of elasticity of 2×105 to about 5×105.