Compounds which modulate the CB2 receptor

摘要

Compounds of formula (I);
are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.

主权项

1. A compound of the formula (I): wherein R1 is methyl, ethyl, propyl, butyl, pentyl, hexyl, heptyl, octyl, nonyl or decyl, each substituted with tetrahydrofuranyl, tetrahydropyranyl or pyrrolidinyl or R1 is tetrahydropyranyl optionally substituted with cyano, fluoro, chloro or bromo; R2 and R3 are independently hydrogen, methyl, ethyl, n-propyl, isopropyl, isobutyl, tert-butyl, wherein R2 and R3 cannot simultaneously be hydrogen, or R2 and R3 together with the carbon to which they are attached form a cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl or tetrahydropyranyl ring; R4 is hydrogen; R5 is phenyl, naphthyl, pyridinyl, quinolinyl, isoquinolinyl, pyrrolyl, pyrazolyl, imidazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, triazolyl, oxadiazolyl, thiadiazolyl, indolyl, benzoxazolyl, benzopyrazolyl, benzoisoxazolyl, benzothiazolyl, benzoisothiazolyl, benzimidazolyl, tetrahydrobenzoxazolyl, tetrahydrobenzothiazolyl or tetrahydrobenzimidazolyl each optionally independently substituted with 1 to 3 substituents chosen from C1-C6 alkyl optionally substituted with 1 to 3 halogen atoms, C3-C6 cycloalkyl, halogen, cyano, dimethylaminoC1-C4alkyl and phenyl optionally substituted with 1 to 2 halogen atoms or C1-C4 alkyl optionally substituted with halogen; or a tautomer or pharmaceutically acceptable salt thereof.