| 发明名称 | Compounds and methods for the treatment or prevention of <i>Flavivirus </i>infections | ||
| 摘要 | Compounds represented by formula:; Wherein X, Y and Z are as defined herein, pharmaceutically acceptable salts thereof, and related compounds, are suitable for use in treating or preventing a Flaviviridae viral infection in a host. | ||
| 申请公布号 | US8829030(B2) | 申请公布日期 | 2014.09.09 |
| 申请号 | US201213690290 | 申请日期 | 2012.11.30 |
| 申请人 | Vertex Pharmaceuticals (Canada) Incorporated | 发明人 | Chan Chun Kong Laval;Das Sanjoy Kumar;Nguyen-Ba Nghe;Halab Liliane;Hamelin Bettina;Pereira Oswy Z.;Poisson Carl;Proulx Melanie;Reddy Thunkunta Jagadeeswar;Zhang Ming Qiang |
| 分类号 | A61K31/4535;C07D409/12 | 主分类号 | A61K31/4535 |
| 代理机构 | Honigman Miller Schwartz and Cohn | 代理人 | Honigman Miller Schwartz and Cohn ;Soulier Kathryn D.;O'Brien Jonathan P. |
| 主权项 | 1. A compound of formula: or pharmaceutically acceptable salts thereof; wherein; Z is piperidinyl or N—C1-6 alkyl-piperidinyl; Y is 6-10 membered aryl; X is 3-10 membered cycloalkyl; m is an integer from 0-1; provided that when Y is unsubstituted phenyl then X is other than 4-methylcyclohexane. | ||
| 地址 | CA | ||