Triazole compounds as potential anti-inflammatory agents

摘要

The present invention relates to a compound of formula 1 or 2;
wherein R1 represents straight-chain or branched C2-C8 alkyl, C2-C8 alkenyl, optionally substituted by at least one substituent selected from the group consisting of hydroxyl, amino or C1-C6 alkyl amino group, or C2-C4 alkynyl, optionally substituted by at least one substituent selected from the group consisting of hydroxyl, amino or C1-C6 alkyl amino group; and R2 represents hydroxyl, C1-C6 alkyl, C1-C6 alkylcarbonyl, di(C1-C6-alkyl)aminomethyl, C3-C6 heterocyclylmethyl or arylaminomethyl, wherein the aryl group is optionally substituted by at least one substituent selected from the group consisting of halogens and C1-C6 alkoxy as well as associated pharmaceutical compositions and uses of the compound or composition in therapy, in particular for the treatment of a disorder or a disease susceptible to inhibition of COX-2.

主权项

1. A compound of formula 1 or 2 wherein wherein R1 is selected from the group consisting of 1-pentyl, 2-pentyl, 3-pentyl, cyclopentyl, 1-hexyl, 2-hexyl, 3-hexyl, pent-4-enyl and propynyl; and R2 is selected from the group consisting of hydroxymethyl, ethoxycarbonyl, dimethylaminomethyl, diethylaminomethyl, pyrrolidinylmethyl, unsubstituted and substituted phenylaminomethyl and benzylaminomethyl, wherein the phenyl or benzyl group is mono- or disubstituted by halogen.