| 发明名称 | Methods for treating IgE-mediated disorder | ||
| 摘要 | This invention relates to methods of treating IgE mediated disorders such as allergy and asthma based on activating surface-bound IgD molecules on basophils. The invention also relates to methods of making IgD, as well as methods of screening for antimicrobial agents from IgD-activated basophils. | ||
| 申请公布号 | US8828394(B2) | 申请公布日期 | 2014.09.09 |
| 申请号 | US201013260008 | 申请日期 | 2010.04.01 |
| 申请人 | Cornell University | 发明人 | Cerutti Andrea;Chen Kang |
| 分类号 | A61K39/395;A61K38/16;C07K16/42 | 主分类号 | A61K39/395 |
| 代理机构 | Scully, Scott, Murphy & Presser, P.C. | 代理人 | Scully, Scott, Murphy & Presser, P.C. |
| 主权项 | 1. A method of attenuating an IgE-mediated response from basophils in a subject having an IgE-mediated disorder, comprising administering to said subject an unconjugated anti-IgD antibody that causes cross-linking of IgD pre-bound to the surface of said basophils to attenuate said IgE-mediated response from basophils thereby treating said IgE-mediated disorder. | ||
| 地址 | Ithaca NY US | ||