Compounds, compositions and methods for the treatment of beta-amyloid diseases and synucleinopathies

摘要

Dihydroxyaryl compounds and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of β-amyloid diseases, such as observed in Alzheimer's disease, and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment.

主权项

1. A compound selected from the group consisting of: where R1, R2, R3, and R4 are independently positioned hydroxyl groups and R is selected from a sulfonamide, heteroaryl, tricycloalkyl or pharmaceutically acceptable esters or salts thereof and where the heteroaryl is selected from an imidazole or triazole.