Embedding and encapsulation of sensitive components into a matrix to obtain discrete controlled release particles

摘要

Controlled release, discrete, solid particles which contain an encapsulated and/or embedded component such as a heat sensitive or readily oxidizable pharmaceutically, biologically, or nutritionally active component are continuously produced without substantial destruction of the matrix material or encapsulant. A release-rate controlling component is incorporated into the matrix to control the rate of release of the encapsulant from the particles. The additional component may be a hydrophobic component or a high water binding capacity component for extending the release time. The plasticizable matrix material, such as starch, is admixed with at least one plasticizer, such as water, and at least one release-rate controlling component under low shear mixing conditions to plasticize the plasticizable material without substantially destroying the at least one plasticizable material and to obtain a substantially homogeneous plasticized mass. The plasticizer content is substantially reduced and the temperature of the plasticized mass are substantially reduced prior to admixing the plasticized mass with the encapsulant to avoid substantial destruction of the encapsulant and to obtain a formable, extrudable mixture. The mixture is extruded through a die without substantial or essentially no expansion and cut into discrete, relatively dense particles. Release properties may also be controlled by precoating the encapsulant and/or coating the extrudate particles with a film-forming component.

主权项

1. An encapsulated product comprising discrete, solid particles having a substantially uniform shape and a diameter of up to about 10 mm, wherein each particle comprises:
a plasticized matrix material comprising a partially gelatinized starch in an amount of about 40% or more based on the weight of the final product, the plasticized matrix material comprising starch having substantially intact molecules, at least one component for controlling the rate of release of the encapsulant, at least one plasticizer comprising water, and an encapsulant in an amount of from about 1% to about 85% based upon the weight of the plasticized matrix material, the encapsulant dispersed throughout the plasticized matrix material and comprising at least one pharmaceutical component, neutraceutical component, nutritional component, fragrance component, or biologically active component, wherein the encapsulant and plasticized matrix material form an at least substantially homogenous mixture.