Thermogelling anaesthetic compositions

摘要

The present invention relates to a thermogelling pharmaceutical composition comprising local anaesthetics in base form and which is suitable for topical administration. The compositions further comprise a polyoxyethylene castor oil and one or more surfactants to obtain thermogelling characteristics.

主权项

1. A method of treating pain during an obstetric or gynaecological procedure which method comprises:
(i) providing in a container a composition comprising:
1 to 10% by weight of lidocaine in base form, said lidocaine being solubilized in 10 to 30% by weight of a polyoxyethylene castor oil,15 to 30% by weight of one or more non-ionic block copolymers of poly(oxyethylene) and poly(oxypropylene) type, andwater,wherein the pH of the composition is at least the value of the pKa of said lidocaine; and (ii) applying said composition from said container to an internal mucosal surface of a patient in need of such pain treatment by intravaginal, intracervical, pericervical or intrauteral administration wherein the composition after said applying forms a thermogel on said mucosal surface.