| 摘要 |
Novel transition metal complexes of iron, cobalt, ruthenium, osmium, and vanadium are described. The transition metal complexes can be used as redox mediators in enzyme based electrochemical sensors. In such instances, transition metal complexes accept electrons from, or transfer electrons to, enzymes at a high rate and also exchange electrons rapidly with the sensor. The transition metal complexes include at least one substituted or unsubstituted biimidazole ligand and may further include a second substituted or unsubstituted biimidazole ligand or a substituted or unsubstituted bipyridine or pyridylimidazole ligand. Transition metal complexes attached to polymeric backbones are also described. |
| 主权项 |
1. A sensing layer comprising:
a polymeric transition metal complex wherein the polymeric transition metal complex comprises:
a transition metal complex comprising the formula: wherein M is a transition metal; L1 is a ligand comprising a heterocycle and is coordinatively bound to M via a heteroatom of the heterocycle; L2, L3, L4, L5, and L6 are ligands comprising a nitrogen-containing heterocycle, wherein each of L1, L2, L3, L4, L5, and L6 is independently a monodentate ligand or is combined with at least one other ligand to form a multidentate ligand; and wherein at least one of L1, L2, L3, L4, L5, and L6 is covalently coupled to the at least one spacer;
an analyte-responsive enzyme;a polymer backbone; and at least one spacer covalently coupled to the polymer backbone, the at least one spacer comprising at least one non-cyclic functional group selected from the group consisting of —S(O)2NRk—, —OC(O)NRm—, —OC(S)NRn, —C(O)NRt—, —CRv═N—O—, —CRw═NNRx—, and —(SiRyRz)—, and wherein Rk, Rm, Rn, Rt, Ru, Rv, Rw, Rx, Ry, and Rz are independently hydrogen or substituted or unsubstituted alkyl,
wherein the transition metal complex is covalently coupled to the spacer through the substituted or unsubstituted alkyl of the spacer. |
