3-aminomethyl-3, 5, 5-trimethyl cyclohexylamine preparation method

摘要

Provided is a 3-aminomethyl-3,5,5-trimethylcyclohexylamine preparation method. A feeding flow of 3-cyano-3,5,5-trimethylcyclohexylamine is reacted with NH3 and hydrogen in the presence of a hydrogenation catalyst; the method is characterized by: firstly adding a basic compound to the feeding flow of 3-cyano-3,5,5-trimethylcyclohexylamine, and then after a portion of 3-cyano-3,5,5-trimethylcyclohexylamine has reacted, adding an acidic compound to reaction materials for further hydrogenation reaction to prepare the product. The method ensures that the aminonitrile content in the product is low, thus effectively reducing the duration of the reaction and greatly reducing the consumption of the catalyst during the hydrogenation reaction process.

主权项

1. A method for preparing 3-aminomethyl-3,5,5-trimethylcyclohexylamine, the method comprising:
a) reacting 3-cyano-3,5,5-trimethyl-cyclohexanone with NH3 to obtain a product containing 3-cyano-3,5,5-trimethyl-cyclohexylamine; b) mixing the product of step a) with a basic compound in the presence of hydrogen, NH3 and a first hydrogenation catalyst to obtain a product containing 3-aminomethyl-3,5,5-trimethylcyclohexylamine and 3-cyano-3,5,5-trimethyl-cyclohexylamine, wherein the space velocity on the first hydrogenation catalyst is 0.5-10 g of 3-cyano-3,5,5-trimethyl-cyclohexanone/(per ml catalyst per hour); c) mixing the product of step b) with an acidic compound in the presence of hydrogen, NH3 and a second hydrogenation catalyst, wherein the 3-cyano-3,5,5-trimethyl-cyclohexylamine in the product of step b) is converted into 3-aminomethyl-3,5,5-trimethyl-cyclohexylamine.