3′,6-substituted indirubins and their biological applications

摘要

Indirubin derivatives of formula (I) wherein R represents -(A)n- R1 or —CO—N(R2,R3) with •A being C1-C5 alkylene group, optionally substituted by one or several A1 radical, A1 being an halogen Br, OH, OR4 or NH2, R4 being C1-C5 alkyl; —R1 being halogen, OH, N(R2, R3); R2 and R3, identical or different, being C1-C5 alkyl, optionally substituted by A1 such as above defined, or R2 and R3 are part of a cycle with 5 or 6 elements optionally comprising another heteroatom such as O or N; •n=1−5. It also relates to the biological application thereof.;

主权项

1. An indirubin derivative of formula I wherein R represents -(A)n - R1 or —CO—N(R2,R3) with
A being C1-C5 alkylene group, optionally substituted by one or several A1 radical, A1 being an halogen Br, OH, OR4 or NH2, R4 being C1-C5 alkyl;R1 being halogen, OH, N(R2, R3); R2 and R3, identical or different, being C1-C5 alkyl, optionally substituted by A1 such as above defined, or R2 and R3 are part of a cycle with 5 or 6 elements optionally comprising another heteroatom such as O or N;n=1-5, with the exclusion of 2H-indol-2-one, 6-bromo-3-[(3E)-1,3-dihydro-3-[[2-(1-pyrrolidinyl)ethoxy]imino]-2H-indol-2-ylidene]˜1,3-dihydro- , (3Z).