| 摘要 |
The present invention is related to an siRNA comprising an antisense strand and a sense strand, wherein all or a portion of said antisense strand comprises an antisense duplex region, wherein all or a portion of said sense strand comprises a sense duplex region, wherein said antisense duplex region is at least partially complementary to said sense duplex region, wherein said siRNA comprises a duplex region consisting of said antisense duplex region and said sense duplex region, and wherein: a) said antisense strand comprises a nucleotide sequence of SEQ ID NO: 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44, 46, 48, 50, 52, 54, 56, 58, 60, 62, 64, 68, 74, 76, 78, 80, 82, 84, 86, 88, 90, 92, 94, 96, 98, 100, 102 or 104; or b) said antisense strand comprises an antisense duplex region, all or a portion of which, is complementary to a portion of SEQ ID NO: 1 or 70. |
| 主权项 |
1. A siRNA comprising an antisense strand between 19 and 25 nucleotides in length and a sense strand between 19 and 25 nucleotides in length, wherein one or more alternating nucleotides on the sense and/or antisense strands are modified, wherein said antisense strand and said sense strand have a duplex region length consisting of 16, 17, 18, or 19 nucleotides, wherein the duplex region is perfectly complementary or contains 1, 2, 3, 4, or 5 nucleotides that do not base pair and said siRNA comprises the antisense and sense combination of SEQ ID NOs: 14 and 15. |
