Biomaterial containing degradation stabilized polymer

摘要

The invention provides a polymer based material comprising a water binding agent present in an amount sufficient to chemically and/or physically absorb and/or adsorb water to prevent degradation of the polymer. The invention also provides a polymer based material comprising a plasticizer or organic solvent as well as a multi-component material or composite including materials encompassing a second polymer and/or an active agent. The invention further provides a pharmaceutical composition comprising the aforesaid polymer based material, which can be used for treatment of bone, cartilage and/or periodontal defects.

主权项

1. A polymer-comprising material consisting of
(a) a plasticizer, which is a water-soluble or water-miscible organic solvent, (b) a water-degradable, water-insoluble polymer, (c) a water-binding agent selected from the group consisting of dewatered calcium sulfate dehydrate, calcium sulfate anhydrous, sodium sulfate anhydrous, magnesium sulfate anhydrous, magnesium ethanolate, calcium ethanolate, aluminum ethanolate, and a mixture thereof, and (d) a pore initiating filler comprising mannitol.