摘要 |
The present invention provides 4H,6H-5-oxa-2,3,10b-triaza-benzo[e]azulenes of the formula;wherein R1 and R2 are as defined herein andwhich act as V1a receptor modulators, and in particular as V1a receptor antagonists, their manufacture, pharmaceutical compositions containing them and their use as medicaments. |
主权项 |
1. A compound of formula Iwherein
R1 is halogen, and R2 is selected from the group consisting of i) heteroaryl, unsubstituted or substituted by 1 to 3 substituents individually selected from the group consisting of OH, halogen, cyano, C1-6-alkyl, C1-6-alkoxy, halogen-C1-6-alkyl, halogen-C1-6-alkoxy, C1-6-alkoxy-C1-6-alkyl and hydroxy-C1-6-alkyl; ii) aryl, unsubstituted or substituted by 1 to 3 substituents individually selected from the group consisting of OH, halogen, cyano, C1-6-alkyl, C1-6-alkoxy, halogen-C1-6-alkyl, halogen-C1-6-alkoxy, C1-6-alkoxy-C1-6-alkyl and hydroxy-C1-6-alkyl; iii) C3-7-cycloalkyl, unsubstituted or substituted by 1 to 3 substituents individually selected from the group consisting of OH, halogen, cyano, C1-6-alkyl, C1-6-alkoxy, halogen-C1-6-alkyl, halogen-C1-6-alkoxy, C1-6-alkoxy-C1-6-alkyl and hydroxy-C1-6-alkyl; and iv) C1-6-alkyl, unsubstituted or substituted by 1 to 3 substituents individually selected from the group consisting of OH, halogen, cyano, C1-6-alkoxy and halogen-C1-6-alkoxy;or a pharmaceutically acceptable salt thereof. |