Antiviral compounds

摘要

Compounds and methods for preventing and treating viral infections are provided. In some embodiments, novel compounds broad-spectrum antiviral activity are provided. In more specific embodiments, the compounds and methods are effective against viruses such as Venezuelan Equine Encephalitis, West Nile Virus, and Hepatitis C.

主权项

1. A compound which has the structure: and its pharmaceutically acceptable salts and hydrates, wherein:
R1 is optionally substituted alkyl,R8 is hydrogen or optionally substituted alkyl,R2, R4, R5, and R7 are hydrogen;R6 is selected from the group consisting of: amino, optionally substituted alkylamino, optionally substituted dialkylamino, and optionally substituted four-, five-, six-, seven-, and eight-membered cycloheteroalkyl, said optionally substituted four-, five-, six-, seven-, and eight-membered cycloheteroalkyl including a first ring nitrogen heteroatom bonded at the position indicated by R3 or R6, respectively, and an optional second heteroatom selected from the group consisting of optionally substituted nitrogen, oxygen, sulfur, optionally substituted sulfinyl, and optionally substituted sulfonyl; and dialkylimino, diarylimino, di-heteroarylimino, alkylarylimino, alkylheteroarylimino, arylheteroarylimino, amino, alkylamino, dialkylamino, alkyloxyalkylamino, di-(alkyloxyalkyl)amino, alkylaminoalkylamino, di-(alkylaminoalkyl)amino, aryloxyalkylamino, di-(aryloxyalkyl)amino, arylaminoalkylamino, di-(arylaminoalkyl)amino, heteroaryloxyalkylamino, di-(heteroaryloxyalkyl)amino, heteroarylaminoalkylamino, and di-(heteroarylaminoalkyl)amino, each of which is optionally substituted; andR3 is optionally substituted morpholin-1-yl wherein said optionally substituted is with a group which is hydrooxyl, nitro, amino, imino, cyano, halo, amidino, oxo, oxamidino, methoxamidino, imidino, guanidino, sulfonamido, carboxyl, formyl, lower alkyl, haloloweralkyl, loweralkoxy, haloloweralkoxy, lower alkoxyalkyl, alkylcarbonyl, arylcarbonyl, aralkylcarbonyl, heteroarylcarbonyl, heteroaralkylcarbonyl, aminoalkyl, or cyanoalkyl or a compound which has the structure: and its pharmaceutically acceptable salts and hydrates, wherein:
R1 is hydrogen or optionally substituted alkyl,R8 is optionally substituted alkyl,R2, R4, R5, and R7 are hydrogen;R6 are selected independently from the group consisting of: amino, optionally substituted alkylamino, optionally substituted dialkylamino, and optionally substituted four-, five-, six-, seven-, and eight-membered cycloheteroalkyl, said optionally substituted four-, five-, six-, seven-, and eight-membered cycloheteroalkyl including a first ring nitrogen heteroatom bonded at the position indicated by R3 or R6, respectively, and an optional second heteroatom selected from the group consisting of optionally substituted nitrogen, oxygen, sulfur, optionally substituted sulfinyl, and optionally substituted sulfonyl; and dialkylimino, diarylimino, di-heteroarylimino, alkylarylimino, alkylheteroarylimino, arylheteroarylimino, amino, alkylamino, dialkylamino, alkyloxyalkylamino, di-(alkyloxyalkyl)amino, alkylaminoalkylamino, di-(alkylaminoalkyl)amino, aryloxyalkylamino, di-(aryloxyalkyl)amino, arylaminoalkylamino, di-(arylaminoalkyl)amino, heteroaryloxyalkylamino, di-(heteroaryloxyalkyl)amino, heteroarylaminoalkylamino, and di-(heteroarylaminoalkyl)amino, each of which is optionally substituted; andR3 is optionally substituted morpholin-1-yl wherein said optionally substituted is with a group which is hydrooxyl, nitro, amino, imino, cyano, halo, amidino, oxo, oxamidino, methoxamidino, imidino, guanidino, sulfonamido, carboxyl, formyl, lower alkyl, haloloweralkyl, loweralkoxy, haloloweralkoxy, lower alkoxyalkyl, alkylcarbonyl, arylcarbonyl, aralkylcarbonyl, heteroarylcarbonyl, heteroaralkylcarbonyl, aminoalkyl, or cyanoalkyl.