Bone morphogenetic protein 2 (BMP2) variants with reduced BMP antagonist sensitivity

摘要

The present invention is directed to an isolated peptide comprising or consisting of an amino acid sequence with an amino acid identity of at least 90% compared to mature human BMP2 with SEQ ID No. 1, characterized in that said amino acid sequence comprises at least two amino acid substitutions characterized in that a first amino acid substitution occurs at a position corresponding to N59, S88, E94, V99, K101 and/or N102 of SEQ ID No. 1 and to uses thereof.

主权项

1. An isolated peptide having BMP-2 activity comprising an amino acid sequence having at least 90% sequence identity with SEQ ID No. 1, wherein said amino acid sequence comprises at least a first and second amino acid substitution, wherein the first amino acid substitution occurs at a position corresponding to N59, E94, V99, K101 or N102 of SEQ ID No. 1.