FORMULATIONS FOR A TIGTHT JUNCTION EFFECTOR

摘要

Enteric compositions comprising one or more tight junction agonists and/or one more tight junction antagonists are provided. Compositions of the invention may comprise a delayed-release coating disposed over a tight junction agonist and/or tight junction antagonist layer which may be disposed over an inert core. Delayed-release coatings may be substantially stable in gastric fluid and substantially unstable in itestinal fluid, thus providing for substantial release of the tight junction agonist and/or antagonist from the composition in the duodenum of the small intestine.