SUBSTITUTED AMINOTHIAZOLES AS INHIBITORS OF CANCERS, INCLUDING HEPATOCELLULAR CARCINOMA, AND AS INHIBITORS OF HEPATITIS VIRUS REPLICATION

摘要

Pharmaceutical compositions of the invention are presented which comprise substituted aminothiazoles derivatives. The substituted aminothiazoles derivatives have a disease-modifying action in the treatment of diseases associated with unregulated cell growth. Such diseases include cancers such as hepatocellular carcinoma, and viral infections from a hepatitis virus.

主权项

1. A compound having formula (I): Including hydrates, solvates, pharmaceutically acceptable salts, prodrugs and complexes thereof, wherein: R1 is selected from the group consisting of hydrogen, C1-C9 linear alkyl, isopropyl, cyclohexyl, bromine, cyano, R2 is selected from the group consisting of hydrogen, methyl, isopropyl, tert-butyl, benzyl, and Ar1 is selected from the group consisting of phenyl, Ar2 is selected from the group consisting of phenyl,wherein compounds of the structuresare excluded from the compounds of formula (I).