| 主权项 |
1. A compound of Formula I, or a stereoisomer, tautomer, or pharmaceutically acceptable salt thereof,wherein,
X1, X2, X3 and X4 are CR2 or X3 and X1 are N and X2 is CR2; Y is substituted or unsubstituted amino, alkoxy, cycloalkyl, heterocycloalkyl, aryl or heteroaryl; Z1, Z2 and Z3 are independently selected from CR2 and N; provided that not more than one of Z1, Z2 and Z3 can be N; R1 is selected from the group consisting of hydrogen, halo, alkyl, cycloalkyl, —CN, —NO2, and —NHR3; each R2 is independently selected from the group consisting of hydrogen, halo, hydroxyl, nitro, cyano, SO3H and substituted or unsubstituted alkyl, alkenyl, alkynyl, alkoxy, amino, aminocarbonyl, aminothiocarbonyl, aminocarbonylamino, aminothiocarbonylamino, aminocarbonyloxy, aminosulfonyl, aminosulfonyloxy, aminosulfonylamino, amidino, carboxyl, carboxyl ester, (carboxyl ester)amino, (carboxyl ester)oxy, sulfonyl, sulfonyloxy, thioacyl, thiol, alkylthio, aryl, heteroaryl, cycloalkyl, hetero cycloalkyl, partially saturated cycloalkyl, aryloxy, heteroaryloxy, heterocyclyloxy, cycloalkyloxy, acyl, acylamino and acyloxy; R3 is selected from the group consisting of hydrogen, —CO—R4 and substituted or unsubstituted alkyl, cycloalkyl, heterocyclyl, aryl and heteroaryl; and R4 is selected from the group consisting of alkyl, substituted alkyl, alkoxy, substituted alkoxy, amino, substituted amino, and alkylamino. |
