| 主权项 |
1. A compound of formula (I) in which R1 is hydrogen, halogen, 1-3C-alkyl, R2/R3 are independently from each other hydrogen, halogen, cyano, hydroxy 1-6C-haloalkyl, 1-6C-haloalkoxy, 1-6C-alkoxy, R4 is independently hydrogen, hydroxy, halogen, cyano, NO2, 1-6C-alkyl, 2-6C-alkenyl, 2-6C-alkynyl, 1-6C-haloalkyl, 1-6C-hydroxyalkyl, 1-6C-alkoxy, —O-(2-6C-alkylen)-O—C(O)-(1-6C-alkyl), 1-6C-haloalkoxy, —C(O)OR9, -(1-6C-alkylen)-C(O)OR9, —C(O)-(1-6C-alkyl), —C(O)NR10R11, 3-7C-cycloalkyl, —S-(1-6C-haloalkyl), SF5, —SO2NH-(3-7C-cycloalkyl), —SO2NR10R11, NR10R11,
heteroaryl which optionally is substituted independently one or more times with cyano, 1-4C-alkyl, 1-6C-haloalkyl, 1-6C-haloalkoxy, C(O)OR9, C(O)NR10R11, whereby two of R2, R3 (R4)n, when positioned ortho to each other, may form together with the two carbon atoms to which they are attached, a heterocyclic 5-, 6- or 7-membered ring containing 1 or 2 heteroatoms selected from O or N, and optionally containing an additional double bond and/or optionally substituted by an oxo (═O) group and/or an 1-4C-alkyl group, n 0-3 R6 is (a) hydrogen;
(b) hydroxy;(c) cyano;(d)1-6C-alkoxy optionally substituted independently one or more times with
(d1) OH,(d2) —O-(1-6C-alkyl)(d3) C(O)OR9,(d4) C(O)NR10R11,(d5) NR10R11,(d6) —S-(1-6C-alkyl),(d7) —S(O)-(1-6C-alkyl),(d8) —SO2-(1-6C-alkyl)(d9) SO2NR10R11,(d10) heterocyclyl, which is optionally substituted with C(O)OR9, or oxo (═O),(d11) heteroaryl, which is optionally substituted independently one or more times with cyano, 1-4C-alkyl, 1-6C-haloalkyl, 1-6C-haloalkoxy, C(O)OR9, C(O)NR10R11, (1-6C-alkylen)-O-(1-6C-alkyl),(e) SO2NR10R11,(f)3-7C-cycloalkoxy,(g)1-6C-haloalkoxy,(h) COOR9,(i) —C(O)NR10R11,(j) —O-heteroaryl opt. subst. with CNwhereby the * is the point of attachment,
(l) —O-(2-6C-alkylen)-O-(1-6C-alkyl) which is optionally substituted with hydroxy, NH(CO)OR9, R7 is
(a) hydrogen,(b) 1-6C-alkyl, which is optionally substituted with heteroaryl(c) 1-6C-haloalkyl,(d) 1-6C-hydroxyalkyl,whereby the * is the point of attachment,
(f) —C(O)-(1-6C-alkyl),(g) —C(O)-(1-6C-alkylen)-O-(1-6C-alkyl),(h) —C(O)-(1-6C-alkylen)-O-(2-6C-alkylen)-O-(1-6C-alkyl),(i) —C(O)-heterocyclyl,(j) benzyl whereby the phenyl ring is opt. subst with 1-5 substituents independently selected from the group consisting of hydrogen, halogen, 1-4C-alkyl, 1-4C-haloalkyl, 1-4C-alkoxy, 1-4C-haloalkoxy, cyano, C(O)OR9,(k) heteroaryloroptionally, R6 and R7 together with the nitrogen atom to which R7 is attached form a 6-membered ring which may contain one further heteroatom selected from the group consisting of O, S, N,
and which is optionally substituted by (1-6C-alkyl)-OH, (1-6C-alkyl)-NR10R11, R8 is hydrogen, halogen, hydroxy, cyano, 1-6C-alkyl, 1-6C-hydroxyalkyl, 1-6C-haloalkyl, 1-6C-haloalkoxy, C(O)OR9, C(O)NR10R11, m is 0-4 R9 is (a) hydrogen,
(b) 1-6C-alkyl which optionally is substituted with hydroxy, R10R11 are independently from each other hydrogen, 1-4C-alkyl, 1-4C-hydroxyalkyl, 1-4C-alkoxy, —(CO)-(1-6C-alkyl), CHO, COOR9, or
together with the nitrogen atom to which they are attached form a 4-6-membered heterocyclic ring optionally containing one further heteroatom selected from the group consisting of O, S or N, and which is optionally substituted with 1-2 fluorine atoms or COOR9, or an N-oxide, a salt, a tautomer or a stereoisomer of said compound, or a salt of said N-oxide, tautomer or stereoisomer. |
