发明名称 |
Substituted 7-Oxo-Pyrido[2,3-d]Pyrimidines and Methods of Use |
摘要 |
The invention encompasses compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions, uses and methods for prophylaxis and treatment of cancer. |
申请公布号 |
US2014249131(A1) |
申请公布日期 |
2014.09.04 |
申请号 |
US201414190400 |
申请日期 |
2014.02.26 |
申请人 |
AMGEN INC. |
发明人 |
TASKER Andrew;WURZ Ryan;PETTUS Liping H.;HERBERICH Bradley J. |
分类号 |
C07D471/04 |
主分类号 |
C07D471/04 |
代理机构 |
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代理人 |
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主权项 |
1. A compound of Formula I wherein R1 is wherein Ring A is 5 membered heteroaryl; wherein Ring T is phenyl or 6 membered heteroaryl; wherein R2 is H, F, Cl or methyl; wherein R3 is H, C1-C6 alkyl or C1-C6 dialkylamino-C1-C6 alkyl; wherein R5 is unsubstituted or substituted 5-6 membered saturated heterocyclyl or substituted 4-7 membered heterocyclylamino; wherein R6 is H, C1-C6 alkoxy, C1-C6 haloalkoxy or halo; and wherein X is CH or N; provided R5 is not 4-morpholinyl; and pharmaceutically acceptable salts thereof. |
地址 |
Thouand Oaks CA US |