| 发明名称 |
METHODS OF MAINTAINING, EXPANDING, AND DIFFRENTIATING NEURONAL SUBTYPE SPECIFIC PROGENITORS |
| 摘要 |
Methods for expanding proliferating populations of neuronal subtype-specific progenitors are provided herein. In particular, the present invention provides methods for maintaining the unique gene profile and differentiation potential of neuronal subtype-specific progenitors, such as motor neuron progenitors and hindbrain serotonergic neural progenitors. |
| 申请公布号 |
US2014248696(A1) |
申请公布日期 |
2014.09.04 |
| 申请号 |
US201414194130 |
申请日期 |
2014.02.28 |
| 申请人 |
Wisconsin Alumni Research Foundation |
发明人 |
Zhang Su-Chun;Du Zhong-wei;Lu Jianfeng |
| 分类号 |
C12N5/0797 |
主分类号 |
C12N5/0797 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for maintaining a population of neuronal subtype-specific progenitors, the method comprising culturing neuronal subtype-specific progenitors in a culture medium comprising a Wnt signaling pathway agonist, an inhibitor of the bone morphogenetic protein (BMP) signaling pathway, an inhibitor of the transforming growth factor beta (TGFIβ) signaling pathway, and a Notch signaling pathway agonist, whereby expression of a neuronal subtype-specific progenitor gene expression profile is maintained in the neuronal subtype-specific progenitors. |
| 地址 |
Madison WI US |
