发明名称 |
METHODS OF PRODUCING ENRICHED POPULATIONS OF TUMOR-REACTIVE T CELLS FROM TUMOR |
摘要 |
<p>Methods of obtaining a cell population enriched for tumor-reactive T cells, the method comprising: (a) obtaining a bulk population of T cells from a tumor sample; (b) specifically selecting CD8+ T cells that express any one or more of TIM-3, LAG-3, 4-1BB, and PD-1 from the bulk population; and (c) separating the cells selected in (b) from unselected cells to obtain a cell population enriched for tumor-reactive T cells are disclosed. Related methods of administering a cell population enriched for tumor-reactive T cells to a mammal, methods of obtaining a pharmaceutical composition comprising a cell population enriched for tumor-reactive T cells, and isolated or purified cell populations are also disclosed.</p> |
申请公布号 |
WO2014133567(A1) |
申请公布日期 |
2014.09.04 |
申请号 |
WO2013US38799 |
申请日期 |
2013.04.30 |
申请人 |
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
GROS, ALENA;ROSENBERG, STEVEN, A. |
分类号 |
A61K35/14;C12N5/0783 |
主分类号 |
A61K35/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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