发明名称 |
METHODS OF MODULATING DLK STABILITY |
摘要 |
The invention provides for methods of decreasing dual leucine zipper kinase (DLK) stability in a neuron, or decreasing or inhibiting the phosphorylation of certain amino acid residues of DLK, comprising administering to a neuron, or portion thereof, an agent which decreases or inhibits the phosphorylation of DLK and decreases the stability of DLK as well methods for inhibiting or preventing neuronal degeneration in a patient by administering to a patient an agent which inhibits phosphorylation of dual leucine zipper kinase (DLK). |
申请公布号 |
CA2900553(A1) |
申请公布日期 |
2014.09.04 |
申请号 |
CA20142900553 |
申请日期 |
2014.02.27 |
申请人 |
GENENTECH, INC. |
发明人 |
BUSTOS, DAISY;HUNTWORK-RODRIGUEZ, SARAH;KIRKPATRICK, DONALD;LEWCOCK, JOSEPH WESLEY;GHOSH, ARUNDHATI SENGUPTA |
分类号 |
A61K39/395;A61K31/7105;A61P25/28 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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