发明名称 |
PHARMACEUTICAL COMPOSITION INCLUDING MIGRATORY FACTOR FOR GUIDING PLURIPOTENT STEM CELLS TO INJURY |
摘要 |
The purpose of the present invention is to identify a migratory factor that guides pluripotent stem cells (Muse cells) useful in new medical applications to an injury, and to provide a pharmaceutical composition that includes the migratory factor for promoting tissue regeneration in regenerative medicine that makes use of Muse cells. In the present invention, a receptor that is specifically expressed in Muse cells rather than non-Muse cells was identified, and it was confirmed that a ligand for this receptor can function as a migratory factor. In the present invention, sphingosine-1-phosphate (S1P) was identified as a migratory factor, and thus, the present invention pertains to a pharmaceutical composition for guiding pluripotent stem cells to an injury, the composition including S1P as an active ingredient. |
申请公布号 |
CA2903415(A1) |
申请公布日期 |
2014.09.04 |
申请号 |
CA20142903415 |
申请日期 |
2014.02.28 |
申请人 |
CLIO, INC.;TOHOKU UNIVERSITY;NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY |
发明人 |
DEZAWA, MARI;FUJIYOSHI, YOSHINORI;YOSHIDA, MASANORI |
分类号 |
A61K45/00;A61K31/4164;A61K31/417;A61K31/42;A61K31/4439;A61K31/661;A61K35/12;A61K35/28;A61K35/36;A61P9/10;A61P17/02;A61P29/00;A61P35/00;A61P43/00 |
主分类号 |
A61K45/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|